Anti-LILRA4 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human skin tissue with rabbit anti-LILRA4 antibody IGX-43714 at dilution 1:100.
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Catalog No
IGX-43714
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PMID:16735691, PMID:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades (PMID:16735691, PMID:19564354, PMID:24586760). Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PMID:26172439). Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca2+ (PMID:16735691, PMID:19564354). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells (PMID:24586760). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 protein (289-424AA) |
| Specificity | LILRA4 antibody detects endogenous level of LILRA4 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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