Anti-LRRK2 Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human brain tissue with rabbit anti-LRRK2 antibody IGX-44691 at dilution 1:100.
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Catalog No
IGX-44691
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PMID:20949042, PMID:22012985, PMID:26824392, PMID:29125462, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:30635421, PMID:21850687, PMID:23395371, PMID:17114044, PMID:24687852, PMID:26014385, PMID:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PMID:26824392, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:29125462, PMID:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PMID:26824392, PMID:28720718, PMID:29127255, PMID:30398148, PMID:29212815, PMID:29125462, PMID:30635421, PMID:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of ‘Thr-72’ on RAB8A (PMID:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating ‘Thr-72’ on RAB8A (PMID:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PMID:29125462, PMID:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PMID:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PMID:17114044). Plays a role in synaptic vesicle trafficking (PMID:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PMID:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PMID:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PMID:22012985). Phosphorylates PRDX3 (PMID:21850687). By phosphorylating APP on ‘Thr-743’, which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PMID:28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PMID:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PMID:18230735, PMID:26824392, PMID:29125462, PMID:28720718, PMID:29212815). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 protein (2029-2275AA) |
| Specificity | LRRK2 antibody detects endogenous level of LRRK2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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