Anti-LYAR Antibody
419.42 $ – 243.82 $
Western Blot
analysis of K562 whole cell lysate, HeLa whole cell lysate, SH-SY5Y whole cell lysate, PC-3 whole cell lysate
All lanes: LYAR antibody at 2.5µg/mL
Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-51145
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PMID:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PMID:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PMID:28686580). Preferentially binds to a DNA motif containing 5′-GGTTAT-3′ (PMID:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PMID:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PMID:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells . Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:500-1:1000, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Cell growth-regulating nucleolar protein (1-379AA) |
| Specificity | LYAR antibody detects endogenous level of LYAR protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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