Anti-MANF Antibody
391.24 $ – 243.68 $
Immunohistochemistry of paraffin-embedded human endometrial cancer with rabbit anti-MANF antibody IGX-41925
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Catalog No
IGX-41925
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PMID:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra . Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons . Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PMID:18561914, PMID:22637475, PMID:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PMID:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PMID:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PMID:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PMID:29497057). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein (25-182AA) |
| Specificity | MANF antibody detects endogenous level of MANF protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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