Anti-MAPK15 / ERK7/ERK8 Antibody
391.72 $ – 243.98 $
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Catalog No
IGX-54748
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PMID:22948227, PMID:24618899, PMID:29021280, PMID:21847093, PMID:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PMID:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PMID:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PMID:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PMID:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PMID:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PMID:28842414). In response to H2O2 treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3’UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PMID:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth . Phosphorylates in vitro FOS and MBP (PMID:11875070, PMID:16484222, PMID:20638370, PMID:19166846). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos . Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PMID:21190936). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | IHC, IF, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:5000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from the internal region of human ERK 8. |
| Specificity | MAPK15 antibody detects endogenous level of MAPK15 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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