Anti-MCU Antibody
391.46 $ – 243.82 $
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Catalog No
IGX-54837
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PMID:21685888, PMID:21685886, PMID:23101630, PMID:22904319, PMID:23178883, PMID:22829870, PMID:22822213, PMID:24332854, PMID:23755363, PMID:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PMID:23755363). Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity (PMID:24560927, PMID:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PMID:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a ‘fight-or-flight’ response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PMID:25603276). participates in mitochondrial permeability transition during ischemia-reperfusion injury . Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PMID:22904319, PMID:22829870). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults . Regulates synaptic vesicle endocytosis kinetics in central nerve terminal . Involved in antigen processing and presentation . |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | IHC, ELISA |
| Recommended Dilutions | IHC: 1:100-1:300, ELISA: 1:40000 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide derived from the internal region of human CCDC109A. |
| Specificity | MCU antibody detects endogenous level of MCU protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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