Anti-MFN2 Antibody
418.48 $ – 243.28 $
Immunohistochemistry of paraffin-embedded human heart tissue with rabbit anti-MFN2 antibody IGX-47982 at dilution 1:100
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Catalog No
IGX-47982
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PMID:11181170, PMID:11950885, PMID:26214738, PMID:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PMID:28114303). Overexpression induces the formation of mitochondrial networks (PMID:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes . Plays an important role in the regulation of vascular smooth muscle cell proliferation . Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PMID:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PMID:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress . Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions . |
| Host Species | Rabbit |
| Species Reactivity | Human, Rat |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:200-1:3000, IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Mitofusin-2 protein (61-158AA) |
| Specificity | MFN2 antibody detects endogenous level of MFN2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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