Anti-MLLT3 Antibody
389.62 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human liver cancer with rabbit anti-MLLT3 antibody IGX-42571
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Catalog No
IGX-42571
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PMID:20159561, PMID:20471948, PMID:25417107, PMID:27105114, PMID:27545619). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated (PMID:25417107, PMID:27105114, PMID:27545619, PMID:30374167, PMID:30385749). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PMID:25417107, PMID:27105114, PMID:27545619). Recognizes and binds histone H3 crotonylated at ‘Lys-9’ (H3K9cr), and with slightly lower affinity histone H3 crotonylated at ‘Lys-18’ (H3K18cr) (PMID:27105114). Also recognizes and binds histone H3 acetylated and butyrylated at ‘Lys-9’ (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3 (PMID:25417107, PMID:27105114, PMID:30385749). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PMID:27105114, PMID:27545619). Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 ‘Lys-79’ methylation (H3K79me) (PMID:25417107). Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness (PMID:31776511). Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L (PMID:31776511). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Protein AF-9 protein (1-150AA) |
| Specificity | MLLT3 antibody detects endogenous level of MLLT3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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