Anti-NAT10 Antibody
417.46 $ – 242.68 $
IHC staining of paraffin-embedded Human colon cancer tissue
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Catalog No
IGX-55120
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | RNA cytidine acetyltransferase that catalyzes the formation of N4-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PMID:25411247, PMID:25653167, PMID:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PMID:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PMID:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PMID:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA . Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PMID:25411247, PMID:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs . Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PMID:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PMID:14592445, PMID:17631499, PMID:19303003, PMID:26882543, PMID:27993683, PMID:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PMID:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PMID:14592445, PMID:18082603). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | ELISA: 1:2000-1:5000, WB: 1:500-1:2000, IHC: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human NAT10 |
| Specificity | NAT10 antibody detects endogenous level of NAT10 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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