Anti-NAT10 Antibody
417.46 $ – 242.68 $
Immunohistochemical staining with rabbit anti-NAT10 antibody IGX-51047 at 1:300 in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Catalog No
IGX-51047
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | RNA cytidine acetyltransferase that catalyzes the formation of N4-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PMID:25411247, PMID:25653167, PMID:30449621). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PMID:30449621). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PMID:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PMID:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA . Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PMID:25411247, PMID:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs . Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PMID:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PMID:14592445, PMID:17631499, PMID:19303003, PMID:26882543, PMID:27993683, PMID:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PMID:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PMID:14592445, PMID:18082603). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC, IP |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:200-1:500, IP: 1:200-1:2000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human RNA cytidine acetyltransferase protein (909-1025AA) |
| Specificity | NAT10 antibody detects endogenous level of NAT10 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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