Anti-NOV Antibody
419.42 $ – 243.82 $
IHC staining of paraffin-embedded Human ovarian cancer tissue
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Catalog No
IGX-55327
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PMID:15181016, PMID:15611078, PMID:12695522, PMID:21344378, PMID:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PMID:12695522, PMID:21344378, PMID:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PMID:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PMID:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PMID:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PMID:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PMID:15611078). Involved in bone regeneration as a negative regulator . Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PMID:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion . Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PMID:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis . Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PMID:21871891). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:2000, WB: 1:500-1:2000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human NOV |
| Specificity | NOV antibody detects endogenous level of NOV protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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