Anti-NPC1 Antibody
419.70 $ – 243.98 $
IHC staining of paraffin-embedded Human liver cancer tissue
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Catalog No
IGX-55336
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PMID:9211849, PMID:9927649, PMID:10821832, PMID:18772377, PMID:27238017, PMID:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PMID:9211849, PMID:9927649, PMID:18772377, PMID:19563754, PMID:27238017, PMID:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PMID:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). (Microbial infection) Acts as an endosomal entry receptor for ebolavirus. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:2000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human NPC1 |
| Specificity | NPC1 antibody detects endogenous level of NPC1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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