Anti-NRP1 Antibody
418.48 $ – 243.28 $
IHC staining of paraffin-embedded Human esophagus cancer tissue
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Catalog No
IGX-55385
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (PMID:9288753, PMID:9529250, PMID:10688880). It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB (PMID:9288753, PMID:9529250, PMID:10688880). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development . Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PMID:30623799). Binds VEGF-165 and may inhibit its binding to cells (PMID:10748121, PMID:26503042). May induce apoptosis by sequestering VEGF-165 (PMID:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:2000-1:5000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Fusion protein of human NRP1 |
| Specificity | NRP1 antibody detects endogenous level of NRP1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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