Anti-OTULIN Antibody
419.28 $ – 243.74 $
Immunofluorescence staining of U251 cells with rabbit anti-OTULIN antibody IGX-40693
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Catalog No
IGX-40693
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Deubiquitinase that specifically removes linear (‘Met-1’-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PMID:26997266, PMID:23708998, PMID:23746843, PMID:23806334, PMID:23827681, PMID:27523608, PMID:27559085, PMID:24726323, PMID:24726327, PMID:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PMID:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PMID:23746843, PMID:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing ‘Met-1’-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PMID:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PMID:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PMID:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling (PMID:23806334). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IF |
| Recommended Dilutions | IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Ubiquitin thioesterase otulin protein (1-287AA) |
| Specificity | OTULIN antibody detects endogenous level of OTULIN protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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