Anti-PARP14 Antibody
419.28 $ – 243.74 $
Immunofluorescence staining of HepG2 cells with rabbit anti-PARP14 antibody IGX-40499
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Catalog No
IGX-40499
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PMID:16061477, PMID:27796300, PMID:18851833, PMID:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PMID:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at ‘Glu-657’ and ‘Glu-705’, thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PMID:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 ‘Lys-703’ (PMID:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PMID:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PMID:27796300). Mono-ADP-ribosylates PARP9 (PMID:27796300). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IF |
| Recommended Dilutions | IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Poly [ADP-ribose] polymerase 14 protein (1600-1712AA) |
| Specificity | PARP14 antibody detects endogenous level of PARP14 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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