Anti-PECAM1 Antibody
419.18 $ – 243.68 $
IHC staining of paraffin-embedded Human renal cancer tissue
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Catalog No
IGX-55630
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PMID:19342684, PMID:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PMID:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PMID:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PMID:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PMID:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PMID:12110892). Modulates bradykinin receptor BDKRB2 activation (PMID:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PMID:18672896). Induces susceptibility to atherosclerosis . Isoform Delta15: Does not protect against apoptosis. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, IHC |
| Recommended Dilutions | ELISA: 1:1000-1:5000, IHC: 1:25-1:100 |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human PECAM1 |
| Specificity | PECAM1 antibody detects endogenous level of PECAM1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.05% NaN3, 40% Glycerol |
| Formulation | Liquid |
| Purification | Affinity Purified |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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