Anti-PINK1 Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human spleen tissue with rabbit anti-PINK1 antibody IGX-43240
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Catalog No
IGX-43240
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PMID:14607334, PMID:15087508, PMID:19229105, PMID:19966284, PMID:20404107, PMID:20798600, PMID:23620051, PMID:23754282, PMID:23933751, PMID:24660806, PMID:24751536, PMID:24784582, PMID:24896179, PMID:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PMID:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at ‘Ser-65’ of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PMID:24660806, PMID:24751536, PMID:24784582, PMID:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA) |
| Specificity | PINK1 antibody detects endogenous level of PINK1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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