Anti-POLE Antibody
419.70 $ – 243.98 $
Immunohistochemical staining of human breast cancer with rabbit anti-POLE antibody IGX-44635 at dilution 1:100.
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Catalog No
IGX-44635
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Catalytic component of the DNA polymerase epsilon complex (PMID:10801849). Participates in chromosomal DNA replication . Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork . Has 3′-5′ proofreading exonuclease activity that corrects errors arising during DNA replication . Involved in DNA synthesis during DNA repair (PMID:20227374, PMID:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PMID:20227374). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human DNA polymerase epsilon catalytic subunit A protein (1175-1311AA) |
| Specificity | POLE antibody detects endogenous level of POLE protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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