Anti-PPP5C Antibody
418.48 $ – 243.28 $
Western Blot
analysis of U87 whole cell lysate, PC3 whole cell lysate, Mouse lung tissue, Mouse kidney tissue
All lanes: PPP5C antibody at 1:1000
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-49142
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PMID:14734805, PMID:14764652, PMID:14871926, PMID:15383005, PMID:15546861, PMID:16260606, PMID:16790549, PMID:16892053, PMID:19176521, PMID:19948726, PMID:21144835, PMID:22399290, PMID:22781750, PMID:23102700, PMID:9000529, PMID:30699359). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PMID:14734805, PMID:14764652, PMID:14871926, PMID:15383005, PMID:15546861, PMID:16260606, PMID:16790549, PMID:16892053, PMID:19176521, PMID:19948726, PMID:21144835, PMID:22399290, PMID:22781750, PMID:23102700, PMID:9000529, PMID:30699359). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PMID:14871926, PMID:16260606, PMID:21144835). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PMID:23102700). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function . Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 . Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PMID:16790549). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PMID:22781750). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PMID:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 . Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PMID:30699359). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:2000, IHC: 1:200-1:500, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Serine/threonine-protein phosphatase 5 protein (370-488AA) |
| Specificity | PPP5C antibody detects endogenous level of PPP5C protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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