Anti-PRDM16 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human brain tissue with rabbit anti-PRDM16 antibody IGX-44555 at dilution 1:100.
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Catalog No
IGX-44555
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Binds DNA and functions as a transcriptional regulator (PMID:12816872). Displays histone methyltransferase activity and monomethylates ‘Lys-9’ of histone H3 (H3K9me1) in vitro . Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 ‘Lys-9’ trimethylation . Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation . Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism . Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells . Functions as a repressor of TGF-beta signaling (PMID:19049980). Isoform 4: Binds DNA and functions as a transcriptional regulator (PMID:12816872). Functions as a repressor of TGF-beta signaling (PMID:14656887). May regulate granulocyte differentiation (PMID:12816872). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human PR domain zinc finger protein 16 protein (448-683AA) |
| Specificity | PRDM16 antibody detects endogenous level of PRDM16 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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