Anti-PSEN1 Antibody
419.18 $ – 243.68 $
Western Blot
analysis of MCF-7 whole cell lysate
All lanes: PSEN1 antibody at 3µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-48059
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PMID:15274632, PMID:10545183, PMID:10593990, PMID:10206644, PMID:10899933, PMID:10811883, PMID:12679784, PMID:12740439, PMID:25043039, PMID:26280335, PMID:30598546, PMID:30630874, PMID:28269784, PMID:20460383). Requires the presence of the other members of the gamma-secretase complex for protease activity (PMID:15274632, PMID:25043039, PMID:26280335, PMID:30598546, PMID:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PMID:9738936, PMID:10593990, PMID:10899933, PMID:10811883). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PMID:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PMID:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PMID:9738936, PMID:11953314). Required for normal embryonic brain and skeleton development, and for normal angiogenesis . Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PMID:17428795, PMID:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PMID:25394380, PMID:16959576). Involved in the regulation of neurite outgrowth (PMID:15004326, PMID:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:2000-1:10000, IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Presenilin-1 protein (4-218AA) |
| Specificity | PSEN1 antibody detects endogenous level of PSEN1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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