Anti-RNF138 Antibody
419.42 $ – 243.82 $
Immunohistochemistry of paraffin-embedded human placenta tissue with rabbit anti-RNF138 antibody IGX-41672
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Catalog No
IGX-41672
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PMID:26502055, PMID:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PMID:26502055, PMID:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PMID:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PMID:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PMID:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PMID:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PMID:16714285). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase RNF138 protein (2-245AA) |
| Specificity | RNF138 antibody detects endogenous level of RNF138 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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