Anti-SDCBP Antibody
419.28 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human liver tissue with rabbit anti-SDCBP antibody IGX-47999 at dilution 1:100
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Catalog No
IGX-47999
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PMID:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PMID:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PMID:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PMID:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PMID:11498591). May also play a role in vesicular trafficking (PMID:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PMID:10230395). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:200-1:5000, IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Syntenin-1 protein (21-228AA) |
| Specificity | SDCBP antibody detects endogenous level of SDCBP protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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