Anti-SIX1 Antibody
417.46 $ – 242.68 $
Western Blot
analysis of LO2 whole cell lysate, PC-3 whole cell lysate, NIH/3T3 whole cell lysate, Rat liver tissue
All lanes: SIX1 antibody at 2.7µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-50787
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development . Plays an important role in the development of several organs, including kidney, muscle and inner ear . Depending on context, functions as transcriptional repressor or activator . Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PMID:15141091). Mediates nuclear translocation of EYA1 and EYA2 (PMID:19497856). Binds the 5′-TCA[AG][AG]TTNC-3′ motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PMID:27923061, PMID:23435380, PMID:15141091, PMID:19497856). Regulates the expression of numerous genes, including MYC, CCND1 and EZR . Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 . Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex . During myogenesis, seems to act together with EYA2 and DACH2 . Regulates the expression of CCNA1 (PMID:15123840). Promotes brown adipocyte differentiation . |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:200-1:500 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Homeobox protein SIX1 protein (144-262AA) |
| Specificity | SIX1 antibody detects endogenous level of SIX1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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