Anti-SMG6 Antibody
418.43 $ – 243.25 $
Immunohistochemistry of paraffin-embedded human gastric cancer with rabbit anti-SMG6 antibody IGX-43924 at dilution 1:100.
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Catalog No
IGX-43924
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PMID:19179534). May have a general role in telomere regulation (PMID:12676087, PMID:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PMID:12676087, PMID:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PMID:12676087, PMID:12699629). Binds to the single-stranded 5′-(GTGTGG)4GTGT-3′ telomeric DNA, but not to a telomerase RNA template component (TER) (PMID:12676087, PMID:12699629). Plays a role in nonsense-mediated mRNA decay (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (PMID:18974281, PMID:19060897, PMID:20930030, PMID:17053788). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Telomerase-binding protein EST1A protein (251-511AA) |
| Specificity | SMG6 antibody detects endogenous level of SMG6 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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