Anti-SRSF10 Antibody
419.42 $ – 243.82 $
Immunohistochemistry of paraffin-embedded human testis tissue with rabbit anti-SRSF10 antibody IGX-41322
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Catalog No
IGX-41322
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PMID:11684676, PMID:12419250, PMID:14765198). Seems to interfere with the U1 snRNP 5′-splice recognition of SNRNP70 (PMID:14765198). Required for splicing repression in M-phase cells and after heat shock (PMID:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PMID:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PMID:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PMID:12419250). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA) |
| Specificity | SRSF10 antibody detects endogenous level of SRSF10 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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