Anti-SYVN1 Antibody
419.18 $ – 243.68 $
Immunohistochemistry of paraffin-embedded human liver tissue with rabbit anti-SYVN1 antibody IGX-44327 at dilution 1:100.
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Catalog No
IGX-44327
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PMID:12459480, PMID:12646171, PMID:12975321, PMID:14593114, PMID:16289116, PMID:16847254, PMID:17059562, PMID:17141218, PMID:17170702, PMID:22607976, PMID:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PMID:12459480, PMID:12646171, PMID:12975321, PMID:14593114, PMID:16289116, PMID:16847254, PMID:17059562, PMID:17141218, PMID:17170702, PMID:22607976, PMID:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PMID:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PMID:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 . |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase synoviolin protein (338-487AA) |
| Specificity | SYVN1 antibody detects endogenous level of SYVN1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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