Anti-TP53BP1 Antibody
391.32 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human colon tissue with rabbit anti-TP53BP1 antibody IGX-41933
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Catalog No
IGX-41933
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PMID:12364621, PMID:22553214, PMID:23333306, PMID:17190600, PMID:21144835, PMID:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PMID:22553214, PMID:23727112, PMID:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PMID:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at ‘Lys-15’ (H2AK15Ub) and histone H4 dimethylated at ‘Lys-20’ (H4K20me2), two histone marks that are present at DSBs sites (PMID:23760478, PMID:28241136, PMID:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PMID:23345425). Participates in the repair and the orientation of the broken DNA ends during CSR . In contrast, it is not required for classic NHEJ and V(D)J recombination . Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PMID:23727112). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Tumor suppressor p53-binding protein 1 protein (1758-1972AA) |
| Specificity | TP53BP1 antibody detects endogenous level of TP53BP1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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