Anti-TRIB3 Antibody
419.28 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human kidney tissue with rabbit anti-TRIB3 antibody IGX-43237
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Catalog No
IGX-43237
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PMID:15781252, PMID:15775988). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PMID:15781252, PMID:15775988). May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PMID:15781252, PMID:15775988). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity . Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation . May bind directly to and mask the ‘Thr-308’ phosphorylation site in AKT1 . Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PMID:12736262). Interacts with MAPK kinases and regulates activation of MAP kinases (PMID:15299019). Can inhibit APOBEC3A editing of nuclear DNA (PMID:22977230). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Tribbles homolog 3 protein (152-325AA) |
| Specificity | TRIB3 antibody detects endogenous level of TRIB3 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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