Anti-TSC2 Antibody
419.18 $ – 243.68 $
Western Blot
analysis of Mouse lung tissue
All lanes: TSC2 antibody at 2.8µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-46429
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PMID:12271141, PMID:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PMID:15340059). May also play a role in microtubule-mediated protein transport . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 . |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Applications | ELISA, WB, IF |
| Recommended Dilutions | WB: 1:1000-1:5000, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Tuberin protein (1396-1496AA) |
| Specificity | TSC2 antibody detects endogenous level of TSC2 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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