Anti-UBE2O Antibody
418.48 $ – 243.28 $
Western blot
All lanes: UBE2O antibody at 0.8µg/mL + A431 whole cell lysate
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Catalog No
IGX-48296
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PMID:23455153, PMID:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PMID:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PMID:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PMID:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate ‘Lys-63’-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PMID:23452853). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, WB |
| Recommended Dilutions | WB: 1:500-1:2000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA) |
| Specificity | UBE2O antibody detects endogenous level of UBE2O protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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