Anti-UBE2S Antibody
391.32 $ – 243.74 $
Immunohistochemistry of paraffin-embedded human testis tissue with rabbit anti-UBE2S antibody IGX-43093
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-43093
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PMID:22496338). Catalyzes ‘Lys-11’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating ‘Lys-11’-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PMID:19820702, PMID:19822757, PMID:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PMID:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except ‘Lys-48’-linked polyubiquitination (PMID:20061386, PMID:20622874). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC |
| Recommended Dilutions | IHC: 1:20-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Ubiquitin-conjugating enzyme E2 S protein (1-222AA) |
| Specificity | UBE2S antibody detects endogenous level of UBE2S protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
Related Products
-
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page -
419.28 $ – 243.74 $Buy now This product has multiple variants. The options may be chosen on the product page