Anti-UBE3A Antibody
417.46 $ – 242.68 $
Immunohistochemistry of paraffin-embedded human liver cancer with rabbit anti-UBE3A antibody IGX-44571 at dilution 1:100.
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Catalog No
IGX-44571
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PMID:10373495, PMID:16772533, PMID:19204938, PMID:19233847, PMID:19325566, PMID:19591933, PMID:22645313, PMID:24273172, PMID:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PMID:10373495, PMID:19204938, PMID:19325566, PMID:19591933, PMID:22645313, PMID:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PMID:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PMID:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PMID:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC . Synergizes with WBP2 in enhancing PGR activity (PMID:16772533). (Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human Ubiquitin-protein ligase E3A protein (83-234AA) |
| Specificity | UBE3A antibody detects endogenous level of UBE3A protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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