Anti-UGT1A1 Antibody
418.43 $ – 243.25 $
Western Blot
analysis of HepG2 whole cell lysate, SH-SY5Y whole cell lysate, PC-3 whole cell lysate, Rat liver tissue, Mouse liver tissue
All lanes: UGT1A1 antibody at 4.2µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-50978
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite’s water solubility, thereby facilitating excretion into either the urine or bile (PMID:12181437, PMID:15472229, PMID:18004206, PMID:18004212, PMID:18719240, PMID:19830808, PMID:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PMID:12181437, PMID:18004206, PMID:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol (PMID:15472229, PMID:18719240, PMID:23288867). Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates (PMID:17187418, PMID:18004206, PMID:19830808). Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PMID:18052087, PMID:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II (PMID:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PMID:12181437, PMID:18004212, PMID:20610558). Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB, IHC, IF |
| Recommended Dilutions | WB: 1:500-1:5000, IHC: 1:200-1:500, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human UDP-glucuronosyltransferase 1-1 protein (395-482AA) |
| Specificity | UGT1A1 antibody detects endogenous level of UGT1A1 protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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