Anti-vcp Antibody
419.28 $ – 243.74 $
Western Blot
analysis of Zebrafish tissue, Zebrafish brain tissue, Zebrafish heart tissue, Zebrafish eye tissue
All lanes: vcp antibody at 1.8µg/mL
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
IGX-49587
Supplier
ImuGeX
Size
100 μL < 50 μL
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites . Enhances cell cycle progression and inhibits apoptosis at low temperatures (PMID:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy . Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i . May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation . May more particularly play a role in caveolins sorting in cells . By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . |
| Host Species | Rabbit |
| Species Reactivity | Zebrafish |
| Applications | ELISA, WB |
| Recommended Dilutions | WB: 1:500-1:5000 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA) |
| Specificity | vcp antibody detects endogenous level of vcp protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | Concentration can vary between different batches. |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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