Anti-WAC Antibody
419.18 $ – 243.68 $
Immunohistochemistry of paraffin-embedded human brain tissue with rabbit anti-WAC antibody IGX-44233 at dilution 1:100.
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Catalog No
IGX-44233
Supplier
ImuGeX
Size
100 μg < 50 μg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Acts as a linker between gene transcription and histone H2B monoubiquitination at ‘Lys-120’ (H2BK120ub1) (PMID:21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PMID:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PMID:21329877). Positive regulator of amino acid starvation-induced autophagy (PMID:22354037). Also acts as a negative regulator of basal autophagy (PMID:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PMID:26812014). May negatively regulate the ubiquitin proteasome pathway (PMID:21329877). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Applications | ELISA, IHC, IF |
| Recommended Dilutions | IHC: 1:20-1:200, IF: 1:50-1:200 |
| Conjugate | Unconjugated |
| Immunogen | Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA) |
| Specificity | WAC antibody detects endogenous level of WAC protein |
Product Properties
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone ID | |
| Concentration | 1 mg/mL |
| Storage Buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. |
| Formulation | Liquid |
| Purification | This antibody is immunogen affinity purified. |
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. |
| Reactivity Life | 12 months when stored properly according to instructions (provided antibody remains sterile). |
Target Gene
NA
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