APRIL, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 13, A Proliferation Inducing Ligand, TALL-2, TNF and ApoL-related Leukocyte-expressed Ligand 2, TRDL-1, TNF-related Death Ligand 1, TNFSF13, CD256, TALL2, ZTNF2, UNQ383/PRO715)
493.39 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-149653
Supplier
US Biologicals
Size
2 µg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3kD protein, consisting of 146aa. Source: Recombinant protein corresponding to human APRIL, expressed in Hi-5 Insect cells. Biological Activity: Tested by its ability to induce IgM secretion by CpG/CD40L treated human naive B cells, at a concentration of 500ng/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| Source Antigen | Recombinant, Hi-5 Insect cells |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight |
Product Properties
| Storage | -20°C |
| Grade | Highly Purified |
| Purity | ~95% (SDS-PAGE and HPLC) |
| Form | Supplied as a lyophilized powder. |
| Reactivity Life | 6 months |
| Note | For reserch purpose only |
Target Gene
NA
