Atg12, Recombinant, Mouse, aa101-141, His-Tag (Ubiquitin-like Protein ATG12, Autophagy-related Protein 12, APG12-like, Apg12, Apg12l, 4931423H11Rik, A330058M13Rik)
574.35 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-149787
Supplier
US Biologicals
Size
50 µg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. Source: Recombinant protein corresponding to mouse ATG12, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~10kD Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Source Antigen | Recombinant, E. coli |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight | 10 |
Product Properties
| Storage | -70°C |
| Grade | Highly Purified |
| Purity | ~95% |
| Form | Supplied as a liquid in 1X PBS, 0.1% SDS. |
| Reactivity Life | 6 months |
| Note | For reserch purpose only |
Target Gene
NA
