Fibrinogen (Pg & vWF Depleted), Human (Factor 1)
559.21 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-301208
Supplier
US Biologicals
Size
500 mg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source. Source: Fibrinogen, from Human Plasma Molecular Weight: ~330kD Biological Activity: >95% clottable by functional assays Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Source Antigen | Human Plasma |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight | 330 |
Product Properties
| Storage | -70°C |
| Grade | Highly Purified |
| Purity | ~95% (SDS-PAGE) |
| Form | Supplied as a liquid in 20mM sodium citrate-HCl, pH 7.4. |
| Reactivity Life | 12 months |
| Note | For reserch purpose only |
Target Gene
NA
