Fibrinogen, Rabbit
745.65 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-F4215-37
Supplier
US Biologicals
Size
25 mg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Rabbit Fibrinogen is prepared from fresh rabbit plasma using several chromatographic steps. Plasminogen depleted by lysine affinity chromatography. Molecular Weight: 330kD Fibronectin is a high-molecular weight (~440kD) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins.[1] In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans (e.g. syndecans). Fibronectin exists as a dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds.[1] The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms. Two types of fibronectin are present in vertebrates:[1] soluble plasma fibronectin (formerly called “cold-insoluble globulin”, or CIg) is a major protein component of blood plasma (300ug/ml) and is produced in the liver by hepatocytes. Insoluble cellular fibronectin is a major component of the extracellular matrix. It is secreted by various cells, primarily fibroblasts, as a soluble dimer and is then assembled into an insoluble matrix in a complex cell-mediated process. Fibronectin plays a major role in cell adhesion, growth, migration and differentiation, and it is important for processes such as wound healing and embryonic development.[1] Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis.[2] Fibronectin exists as a dimer, consisting of two nearly identical polypeptide chains linked by a pair of C-terminal disulfide bonds.[3] Each fibronectin monomer has a molecular weight of 230-250kD and contains three types of modules: type I, II, and III. All three modules are composed of two anti-parallel β-sheets; however, type I and type II are stabilized by intra-chain disulfide bonds, while type III modules do not contain any disulfide bridges. The absence of disulfide bonds in type III modules allows them to partially unfold under applied force.[4] Three regions of variable splicing occur along the length of the fibronectin monomer.[3] One or both of the “extra” type III modules (EIIIA and EIIIB) may be present in cellular fibronectin, but they are never present in plasma fibronectin. A “variable” V-region exists between III14-15 (the 14th and 15th type III module). The V-region structure is different from the type I, II, and III modules, and its presence and length may vary. The V-region contains the binding site for α4β1 integrins. It is present in most cellular fibronectin, but only one of the two subunits in a plasma fibronectin dimer contains a V-region sequence. |
| Source Antigen | Fresh rabbit plasma |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight |
Product Properties
| Storage | -20°C |
| Grade | Purified |
| Purity | Purified |
| Form | Supplied as a liquid in 20mM sodium citrate-HCl, pH 7.4. |
| Reactivity Life | 12 months |
| Note | For reserch purpose only |
Target Gene
NA
