p21, WAF1, Recombinant, Human (Cip1, Sdi1, Pic1, Wild-type p53-activated Fragment, Tumor Suppressor Protein) discontinued
446.58 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-P1000-62
Supplier
US Biologicals
Size
50ul
Product Overview
Product Properties
Target Gene
Product Overview
| Description | p21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1is a tumor suppressor involved in the pathogenesis of a variety of malignancies. Applications: Suitable for use in ELISA, Inhibition Assays and Western Blot. Other applications not tested. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20/-70°C. Aliquots are stable for at least 6 months at -20/-70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| Source Antigen | Human, Recombinant (E. coli) |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight |
Product Properties
| Storage | -20°C/-70°C |
| Grade | Purified |
| Purity | Purified. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kD including GST. |
| Form | Supplied as a liquid in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% Glycerol. |
| Reactivity Life | 6 months |
| Note | For reserch purpose only |
Target Gene
NA
