Proteinase 3 (PR-3)
818.47 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-208588
Supplier
US Biologicals
Size
100 µg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | The Proteinase-3 (PR-3) antigen is 29kD protein found in the primary granules of neutrophils and monocytes. It is a serine protease with broad proteolytic activity against a variety of extracellular matrix proteins (1). PR-3 is purified fom a human promyelocytic cell line using detergent extraction, salt fractionation, and chromaographic techniques. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various lysosomal enzymes (2). Staining by indirect immunofluorescence (IFA) shows two main staining patterns: cytoplasmic (c-ANCA) and perinuclear (p-ANCA) (2,3). The c-ANCA pattern is caused by autoantibodies to PR-3 (4,5). Anti-PR3 autoantibodies are found in 84-100% of patients with Wegener’s granulomatosis (3,6). In addition, PR-3 antibody titer may correlate with disease activity (2). Source: Purified from a human promyelocytic cell line Applications: Suitable for use in standard solid phase immunoassays. Other applications not tested. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| Source Antigen | Human promyelocytic cell line |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight | 29 |
Product Properties
| Storage | -70°C |
| Grade | Purified |
| Purity | Purified |
| Form | Supplied as a liquid in 0.02M Tris, pH 7.0, 0.1M sodium chloride, 0.02% sodium azide. |
| Reactivity Life | 12 months |
| Note | For reserch purpose only |
Target Gene
NA
