SET 7/9, Histone Methyltransferase, Recombinant, Human
514,241.14 $
For reserch purpose only
Shipping cost plus VAT not included , delivery in 7-14 business days
Catalog No
USB-S1012-23A
Supplier
US Biologicals
Size
500 µg
Product Overview
Product Properties
Target Gene
Product Overview
| Description | Set 7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase. Molecular Weight: 40.7kD (366 amino acids) AA Sequence: MDSDDEMVEE/ AVEGHLDDDG/ LPHGFCTVTY/ SSTDRFEGNF/ VHGEKNGRGK/ FFFFDGSTLE/ GYYVDDALQG/ QGVYTYEDGG/ VLQGTYVDGE/ LNGPAQEYDT/ DGRLIFKGQY/ KDNIRHGVCW/ IYYPDGGSLV/ GEVNEDGEMT/ GEKIAYVYPD/ ERTALYGKFI/ DGEMIEGKLA/ TLMSTEEGRP/ HFELMPGNSV/ YHFDKSTSSC/ ISTNALLPDP/ YESERVYVAE/ SLISSAGEGL/ FSKVAVGPNT/ VMSFYNGVRI/ THQEVDSRDW/ ALNGNTLSLD/ EETVIDVPEP/ YNHVSKYCAS/ LGHKANHSFT/ PNCIYDMFVH/ PRFGPIKCIR/ TLRAVEADEE/ LTVAYGYDHS/ PPGKSGPEAP/ EWYQVELKAF/ QATQQK Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
| Source Antigen | Recombinant, E. coli |
| Reactivity | |
| Cross Reactivity | |
| Applications | |
| Molecular Weight | 40.7 |
Product Properties
| Storage | -20°C |
| Grade | Highly Purified |
| Purity | ~ 95% (SDS PAGE). Endotoxin: ≤1Eu/ug (LAL). |
| Form | Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 0.2M sodium chloride, 5mM DTT and 20% glycerol. |
| Reactivity Life | 6 months |
| Note | For reserch purpose only |
Target Gene
NA
